Corrections

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If we are made aware of errors in the book, we will post corrections here. Thank you for contacting us.

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• p16, figure 1-2: Mediating not Mediatating "between the demands of the id and the external world

• p318: traditional antipsychotics can "worsen" the negative symptoms (not diminish)

• p404: buspirone is a 5-HT1A partial agonist, not antagonist

• p414: clomipramine would have been a better choice of serotonergic TCA, I used imipramine to be consistent with the tables we had made that don't include imipramine

• p530: "Clinicians should also note its frequency, setting, duration, degree of sexual impairment, level of subjective distress, and effects on other areas of functioning (e.g., social, occupational)."

• p681: the sentence "GABA is the major inhibitory neurochemical balancing glutamate, if the benzodiazepine is abruptly discontinued, there is insufficient GABA to balance the glutamate" would be more accurate saying "if the benzodiazepine is abruptly discontinued, there are insufficient GABA-A receptor sensitivity, and too much compensatory glutamate"

Questions from readers (some could be interepreted as errata)

• Chapter 1: Why do you talk about the spirit, the soul, and religion in a psychiatry textbook? Especially right at the beginning. There has been a long and significant abandonment of religion in psychiatry. The cost of those abandonments is not benign. I believe there is significant intersections between conventional therapy, psychiatry, and pastoral counseling. Psychiatrists could  benefit from integrating elements of pastoral counseling into their practice. Existential issues such as meaning, purpose, and spiritual well-being are at the heart of pastoral counseling. As a psychiatrist, I am humbled with religious leaders experience's dating thousands of years compared to a relatively young and still somewhat naive field. Ref: John Oliver (1929): how religious leaders can incorporate psychological insights into their pastoral duties. John Bonnell (1938): Pastoral Psychiatry - advocating for a blend of psychiatric and pastoral care.

• p178: Isn't FIGURE 7-3 "Calculating the sample size required to note a 20% reduction in suicide in a high-risk sample" over the top? While I am not a statistician, I think that the formula is accurate and that this is an essential point. A lot of the studies meant to portray significance on actual suicide risk are simply not powered enough. Famously the VA study of Lithium "adding lithium to existing medication regimens is unlikely to be effective for preventing a broad range of suicide-­related events" based on a study of 519 veterans; much less than the 511,922 potentially necessary to find a 20% reduction in suicide.

• Chapter 8: Can you add more information on school intervention for intellectual disability? Yes, we can do that for the next edition. 

• Chapter 10: Can you add more information on inhalants? Yes, we can do that for the next edition. Working in forensic settings, I have a lot of experience with the use and consequences of those compounds. 

• Chapter 10 & 12 & 26: Can you add more information on deprescribing and antidepressant withdrawal? There was discussion whether to include more about those topics in the book, but it felt too onerous for this edition as likely deserving of its own chapter.

• p339: If you had a mixed episode and a major depressive episode, is your diagnosis major depressive disorder or bipolar? Bipolar per the DSM.

• p536: Can fetishism also include focus on body parts? Here is an improve paragraph on festishism: Fetishism involves a reliance on nonliving objects, specific materials (e.g., leather, rubber), or non-genital body parts as stimuli for sexual arousal and gratification. These objects can function as extensions of the human body, such as articles of clothing. Fetishes exist on a spectrum. For some, it enhances ordinary sexual intimacy, whereas for others, it is a prerequisite. Demographically, the phenomenon is documented and diagnosed almost exclusively in males.

• p615: Can you add psychedelic assisted therapy for treatment resistant depression? In 2025, there were no psychedelics approved for depression. The MDMA assisted psychotherapy was for PTSD and wasn't approved by the FDA. Psilocybin is currently in trials. DT120 (LSD formulation), BPL-003 (5-MeO-DMT), Luvesilocin (Psilocyn), are also in trial. 

• Chapter 25: Can you add more on intersubjective psychoanalytic theory? Yes, we can do that for the next edition. I spoke on this here. 

• p625: Can you discuss the Rogerian triad, the core conditions of person-centered therapy? In his seminal 1957 article "The Necessary and Sufficient Conditions of Therapeutic Personality Change" Rogers wrote about the 6 necessary condition for therapeutic change to occur. Here paraphrased: 1. Therapy contact. 2. A patient who is hurting. 3. A therapist who is healthy and engaged. 4. The therapist has "unconditional positive regard", acceptance. 5. The therapist is experiencing an accurate, empathic understanding of the client. 6. The patient feels the empathy and acceptance of the therapist. The last three are usually considered the Rogerian triad. DOI: 10.1037/0033-3204.44.3.240 Link

• p626: Can you better explain the core philosophy of transpersonal/transcendental psychotherapy? The core of human identity is not limited to the individual ego, but is an expression of a deeper, unified consciousness. Like waves from the ocean, our individual selves are distinct but inseparable from a transcendent, universal whole.

• p662 & 668: Isn't mirtazapine also adrenergic? Yes, our psychopharmacology circles include NET and Alpha-1 but not Alpha-2. This matters for a fair number of compounds, especially mirtazapine, but also mianserin, yohimbine, clonidine, guanfacine, dexmedetomidine, clozapine, asenapine, risperidone, norquetiapine. However, remember that alpha-2 is a presynaptic receptor (the "brakes") if you are an agonist you actually decrease NE tone, and vice-versa. 

• p662 & 668: Does buspirone have SERT activity? Not in a significant manner, this was a remnant of how some lab report low activity as 1,000 or >1,000, which was coded as 1,000 and still showed in its effect considering buspirone is a relatively low potency compound.

• p662 & 668: Isn't venlafaxine more 5-HT>>NE than in the psychopharmacology circles? Many publication have venlafaxine as very similar to an SSRI with little NET effects. Due to the variation between labs on Ki, we tried to minimize the number of different sources that we used, and ended up using Sánchez & Hyttel, 1999, which showed Ki of 210 and 640 for 5-HT and NE respectively (smaller number = stronger affinity)

• p690: Can you talk more about alternative medicine compounds? We on p371 in mood disorders "In certain patients, consideration can be made for alternative treatment, including lavender oil, omega-­ 3 fatty acids (Liao et al., 2019), folate (Roberts et al., 2018), s-­ adenosyl-­ l-­ methionine (SAMe; Alpert et al., 2004), magnesium (Eby et al., 2006), tryptophan (Angst et al., 1977), zinc (Siwek et al., 2009), d-­ cycloserine (Heresco-­ Levy et al., 2013), inositol (Mukai et al., 2014), rhodiola rosea (Konstantinos & Heun, 2020), and Crocus sativus (saffron; Dai et al., 2020). With all patients, discussion of light therapy, exercise, and diet should A meta-­ analysis of adjunct light therapy with 858 patients with nonseasonal depression found it effective (de Almeida et al., 2024)."

• p696: Should it say mu opioid agonism instead of antagonism? No, the study by Williams et al. 2018 gave naltrexone blocking opioid receptors and found that the effect of Ketamine were attenuated.